Research

Center for Genetic Studies & Research

Our Genetic Research Group have been working in the area of Clinical Genetics and various aspect of apoptosis, anxiety, toxicity, inflammation, drug discovery and drug screening research using zebrafish as an animal model for the past three years and the outcome of their research work have appeared in various national and international peer reviewed journals.

Publications

Gunalan B, Joseph B, Jyothi S, Sundar R, Sangeetha S, Bibhas Kar (2012) Isolation and preliminary screen of bioactive fractions from different microbial isolates towards construction of a microbial drug bank. Int J Drug Design Dis. 3(2): 753-756.

Jyothi S, Sivamani S, Joseph B, Gunalan B, Moganti V, Bibhas Kar (2012) Effect of bioactive compound from endophytic fungus in anxiety induced zebrafish animal model. In: Proc. of SBTI - Current Scenario in Biotechnology, Bloomsbury Publishing India Pvt. Ltd., New Delhi, 351-364.

Sivamani S, Jyothi S, Joseph B, Gunalan B, Venkatesh B, Bibhas Kar (2013) Synthesis of antibacterial silver nanoparticles from tea powder. Int J Nanosci & Nanotech. 4(1): 9-17.

Sivamani S, Bibhas Kar (2013) Adult zebrafish as a new animal model to study anxiety. Asian J Exp Biol Sci. 4(2): 167-171.

Sivamani S, Joseph B, Nishwetha K, Bibhas Kar (2013) Zebrafish as a model for bioavailability testing of over the counter drug. Int J Drug Dev & Res. 5(2):159-163.

Bibhas Kar, Sivamani S (2013) Zebrafish: An in vivo model for the study of human diseases. Int J Genet & Genom. 1(1): 6-11.

Sivamani S, Joseph B, Bibhas Kar (2013) Zebrafish: An in vivo model for the study of liposome mediated drug delivery. Int J Mol Genet. 3(1): 53-61.

Sivamani S, Joseph B, Bibhas Kar (2014) Anti-inflammatory activity of Withania somnifera leaf extract in stainless steel implant induced inflammation in adult zebrafish. J Genet Eng & Biotech. 12: 1-6.

B Kar (2014) Prenatal diagnosis of partial trisomy 21 associated with maternal balanced translocation 46,XX,der(21)t(21;22) with pericentric inversion of chromosome 9. J Postgrad Med. 60(4): 413.

Bibhas Kar, S. Sivamani (2014) Apoptosis: Basic concepts, mechanisms and clinical implications. Int J Pharm Sci Res. (In press)

S. Sivamani, K. Sivakumar, Bibhas Kar (2014) Sex chromosome pentasomy 49,XXXXY syndrome with pulmonary atresia and ventricular septal defect: a case report. Ind J Hum Genet. (in press)

Conference Presentations

Joseph B, Gunalan B, Jyothi S, Bibhas Kar. Cicer arietinum sprout extract promotes stem cell regeneration in the zebrafish model. XXXV All India Cell Biology Conference, National Institute of Scientific Education & Research (NISER), Bhubaneswar. December 16-18, 2011.

Jyothi S, Sivamani S, Joseph B, Gunalan B, Moganti V, Bibhas Kar. Effect of bioactive compound from endophytic fungus in anxiety induced zebrafish animal model. Annual Meeting of the Society for Biotechnologists (INDIA) and the National Conference on “Current Scenario in Biotechnology”, K.S.R College of Technology, Tiruchengode. September 27-29, 2012.

Sivamani S, Jyothi S, Joseph B, Gunalan B, Venkatesh B, Bibhas Kar. Synthesis of antibacterial silver nanoparticles from tea powder. National Conference on Nanomaterials (NCN 2012), Karunya University, Coimbatore. December 3-4, 2012.

Bibhas Kar, Praveena KK, Kundavi S, Varma TR, Kadandale JS. Cytogenetics and Y chromosome microdeletion screening of infertile males with azoospermia and Oligospermia. 38th Annual Conference of the Indian Society of Human Genetics (ISHG 2013): Genomics and Community Health and International Symposium on Developmental and Complex Disorders. Banaras Hindu University, Varanasi. December 9-11, 2012.

Sivamani S, Joseph B, Bibhas Kar. Expression of TNFα gene in stainless steel implant induced zebrafish. The Centenary Session of the Indian Science Congress, University of Calcutta, Kolkata. January 3-7, 2013.

Bibhas Kar, Praveena KK, Suresh Kumar R, Mullasari Ajit S, Vimalarani A, Kadandale JS. Molecular cytogenetics characterization of 22q11.2 deletion in patients with tetralogy of fallot. HGM 2013 & 21st International Congress of Genetics, Marina Bay Sands, Singapore. April 13-18, 2013.

Bibhas Kar, Sivamani S, Kundavi S, Varma TR. Sensorineural hearing loss and male infertility a case report. 5th Pan Arab Human Genetics Conference and 2013 Golden Helix Symposium – Genomics into Healthcare, Dubai, United Arab Emirates. November 17–19, 2013.

Sivamani S, Joseph B, Bibhas Kar. Zebrafish: An in vivo model for the study of liposome mediated drug delivery. XXXVII All India Cell Biology Conference and Symposium on Cell Dynamics and Cell Fate. Indian Institute of Science, Bangalore. December 22-24, 2013.

Bibhas Kar, Sivamani S, Kundavi S, Varma R Varma. ICSI outcome in infertile males presented with globozoospermia. 20th International Chromosome Conference (ICCXX).University of Kent, Canterbury, UK, September 1-5, 2014.

Sivamani S, Sivakumar K, Bibhas Kar. Sex chromosome pentasomy 49, XXXXY syndrome with pulmonary atresia and ventricular septal defect: a case report. 20th International Chromosome Conference (ICCXX). University of Kent, Canterbury, UK, September 1-5, 2014.

Bibhas Kar, S. Sivamani, G Kalpana, K Sivakumar. Clinical and molecular cytogenetic characterization of Williams syndrome. 64th Annual Meeting of the American Society of Human Genetics (ASHG 2014). San Diego, California, USA. October 18-22, 2014.